Heidelberg University
Cellnetworks Core Technology Platform logo

Protein Crystallization Platform Structure Gallery

Here we present some of the protein structures recently elucidated using crystals grown at our protein crystallization platform.

Structure of fungal tRNA ligase Trl1 with RNA reveals conserved substrate-binding principles

Koehler et al. (2025)

Nat Struct Mol Biol

Strand-Swapped SH3 Domain Dimer with Superoxide Dismutase Activity

Haege, Schwan et al. (2025)

ACS Cent Sci. 11 157-166

Structural and mechanistic insights into activation of human RNA ligase RTCB by Archease

Gerber et al. (2024)

Nat Commun 15 2378

Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.

Klein et al. (2024)

Nat Commun 15 716

Structural basis for binding of Drosophila Smaug to the GPCR Smoothened and to the germline inducer Oskar.

Kubikova et al. (2023)

PNAS 120 e2304385120

Mechanistic insights into RNA surveillance by the canonical poly(A) polymerase Pla1 of the MTREC complex.

Soni et al. (2023)

Nat Commun. 14 772

Structural and functional characterization of the N-terminal acetyltransferase Naa50.

Weidenhausen et al. (2021)

Structure 29 413-425

Structural basis of Naa20 activity towards a canonical NatB substrate.

Layer et al. (2021)

Commun Biol 4 2

Nanobody-Mediated Neutralization Reveals an Achilles Heel for Norovirus.

Koromyslova et al. (2020)

J Virol. 94 e00660-20

Structural basis for the complex DNA binding behavior of the plant stem cell regulator WUSCHEL.

Sloan et al. (2020)

Nat Commun. 11 2223

The Arabidopsis Nα-acetyltransferase NAA60 locates to the plasma membrane and is vital for the high salt stress response.

Linster, Layer et al. (2020)

New Phytol. 228 554-569

The ribosome-associated complex RAC serves in a relay that directs nascent chains to Ssb.

Zhang, Gese et al. (2020)

Nat Commun. 11 1504

Structural Basis of Nanobodies Targeting the Prototype Norovirus.

Ruoff et al. (2019)

J Virol. 93 e02005-18

Structural analysis of a replication protein encoded by a plasmid isolated from a multiple sclerosis patient.

Kilic et al. (2019)

Acta Cryst. D75 498-507

DENR–MCTS1 heterodimerization and tRNA recruitment are required for translation reinitiation.

Ahmed et al. (2018)

PLOS Biol 16 e2005160

Atomic Structure of the Murine Norovirus Protruding Domain and Soluble CD300lf Receptor Complex.

Kilic et al. (2018)

J Virol. 92 e00413-18

Molecular Mechanism of J-Domain-Triggered ATP Hydrolysis by Hsp70 Chaperones.

Kityk et al. (2018)

Mol Cell 69 227-237

Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes.

Kater et al. (2017)

Cell 171 1599-1610

Structure of Naa15/Naa10 bound to HypK-THB.

Weyer et al. (2017)

Nat Commun. 8 15726

9 angstrom structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments.

Dodonova et al. (2017)

Elife 6 e26691

Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis.

Rodrigues et al. (2017)

Nat Chem Biol. 13 290-294

Structural insights into a unique Hsp70-Hsp40 interaction in the eukaryotic ribosome-associated complex.

Weyer et al. (2017)

Nat Struct Mol Biol. 24 144-151

Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain.

Gumiero et al. (2016)

Nat Commun. 7 13563

Structural analysis of bovine norovirus protruding domain.

Singh et al. (2016)

Virology 487 296-301

Structural basis for cpSRP43 chromodomain selectivity and dynamics in Alb3 insertase interaction.

Horn et al. (2015)

Nat Commun. 6 8875

Plasmodium falciparum antioxidant protein reveals a novel mechanism for balancing turnover and inactivation of peroxiredoxins.

Staudacher et al. (2015)

Free Radic Biol Med. 85 228-236

Symportin 1 chaperones 5S RNP assembly during ribosome biogenesis by occupying an essential rRNA-binding site.

Calvino et al. (2015)

Nat Commun. 6 6510

Structure of the complete bacterial SRP Alu domain.

Kempf et al. (2014)

Nucleic Acids Res. 42 12284-12294

SRP RNA remodeling by SRP68 explains its role in protein translocation.

Grotwinkel et al. (2014)

Science 344 101-104

Structural characterization of a eukaryotic chaperone--the ribosome-associated complex.

Leidig et al. (2013)

Nat. Struct. Mol. Biol. 20 23-28

Structure and dynamics of the ATP-bound open conformation of Hsp70 chaperones.

Kityk et al. (2012)

Mol. Cell 48 863-874

Synchronizing nuclear import of ribosomal proteins with ribosome assembly.

Kressler et al. (2012)

Science 338 666-671

Structural basis for tail-anchored membrane protein biogenesis by the Get3-receptor complex.

Stefer et al. (2011)

Science 333 758-762

Deutsch

Contact